Other Names:
, N-t-butoxycarbonyl isonipecotic acid, 1-Boc-isonipecotic acid
Boc-Piperidine-4-carboxylic acid (CAS 84358-13-4) is a white solid commonly used as an 𝑁-protected amino acid building block in pharmaceutical synthesis and peptide chemistry. It serves as a key intermediate for developing drugs targeting neurological disorders, pain management, and inflammation, often in solid-phase peptide synthesis (SPPS) to introduce constrained structures.
Key Uses and Applications:
Pharmaceutical Intermediates:
, Used in the development and synthesis of various drug molecules, specifically as a protected form of isonipecotic acid.
- Peptide Chemistry: Boc-Piperidine-4-Carboxylic Acid CASNO: 84358-13-4, Acts as a non-standard amino acid analog (Boc-Inp-OH) to introduce rigid, cyclic structures into peptide sequences, particularly within Solid-Phase Peptide Synthesis (SPPS) workflows.
- Organic Synthesis: Serves as a versatile building block for creating complex heterocyclic compounds.
- Chemical Research: Used as a reagent in medicinal chemistry to develop compounds targeting inflammatory conditions and neurological disorders.
- Solubility: Soluble in organic solvents such as DMF, DCM, and methanol; insoluble in water.
- Structure: Piperidine ring with protected nitrogen (Boc) and a free carboxylic acid, allowing selective reactions.
The CAS number is 84358-13-4. It is mainly used in drug development, peptide synthesis, and as an intermediate in organic chemistry. It is generally available in 98% or higher purity, depending on the supplier. Yes, it is widely used in laboratories for pharmaceutical and chemical research.
