36082-50-5

5-Bromo-2,4-Dichloro Pyrimidine CASNO:36082-50-5

5-Bromo-2,4-dichloropyrimidine (CAS Number: 36082-50-5) is a halogenated heterocyclic aromatic compound frequently used as a building block and intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its role in forming trisubstituted pyrimidines, particularly in the development of targeted therapies for cancer and infectious diseases.

Chemical Properties

CAS Number: 36082-50-5

Molecular Formula: C₄HBrCl₂N₂

Molecular Weight: 227.87 g/mol

Appearance: White to off-white solid or colorless to pale yellow liquid (melting point is near room temperature)

Melting Point: 29-30 °C (lit.)

Boiling Point: 128 °C at 15 mmHg

Density: ~1.781 g/mL at 25 °C

Solubility: Soluble in organic solvents such as methanol

Stability: Stable under recommended storage conditions (store under inert gas)

Synonyms

2,4-dichloro-5-bromopyrimidine

5-Bromo-2,4-dichloro-pyrimidine

2,4-Dichloro-5-bromo pyrimidine

5-Bromo-2,4-dichloropyrimidinePyrimidine, 5-bromo-2,4-dichloro-

NSC 152517

MFCD00127818

 

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Uses and Applications

5-Bromo-2,4-dichloropyrimidine is a versatile intermediate in organic synthesis and industrial applications:

  • Pharmaceutical Intermediate: It is used in the synthesis of various pharmaceutical ingredients, including Pazopanib hydrochloride, Trilaciclib hydrochloride, Palbociclib Hydrochloride, and Ribociclib succinate. It is also employed in the synthesis of positive allosteric modulators for GABAB receptors.
  • Agrochemical Development: It acts as a key intermediate in the synthesis of herbicides and fungicides.
  • Biochemical Research: It is used as a building block for synthesizing nucleoside analogs, crucial for studying DNA and RNA processes.
  • Material Science: It is employed in the production of specialty polymers and coatings, providing enhanced durability.

Safety and Handling

Danger: This compound is classified as hazardous, causing severe skin burns and eye damage.

Toxicity: It is toxic if swallowed, in contact with skin, or if inhaled.

Handling: Use in a chemical fume hood with appropriate personal protective equipment (PPE), including gloves and eye protection.

Storage: Store in a cool, dry place, typically at 2-8°C or room temperature, under inert gas.

 

What is 5-Bromo-2,4-Dichloro Pyrimidine?
It is a halogenated pyrimidine compound used as an important intermediate in pharmaceutical and specialty chemical synthesis.
What is the CAS number of this compound?

The CAS number is 36082-50-5, which uniquely identifies 5-Bromo-2,4-Dichloro Pyrimidine.

What are its main applications?
It is widely used in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced chemical research.
Why is it valuable in pharmaceutical development?

Its multiple halogen substitutions (bromo and chloro groups) make it highly reactive and useful for building complex drug molecules.

What purity levels are typically available?

This compound is generally supplied in high purity grades (≥98%), suitable for research and industrial use.

FAQs

What is 5-Bromo-2,4-Dichloro Pyrimidine?
It is a halogenated pyrimidine compound used as an important intermediate in pharmaceutical and specialty chemical synthesis.
What is the CAS number of this compound?

The CAS number is 36082-50-5, which uniquely identifies 5-Bromo-2,4-Dichloro Pyrimidine.

What are its main applications?
It is widely used in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced chemical research.
Why is it valuable in pharmaceutical development?

Its multiple halogen substitutions (bromo and chloro groups) make it highly reactive and useful for building complex drug molecules.

What purity levels are typically available?

This compound is generally supplied in high purity grades (≥98%), suitable for research and industrial use.

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