Boc-L-Pyroglutamic Acid Methyl Ester CASNO:108963-96-8

Boc-L-Pyro glutamic Acid Methyl Ester (CAS: 108963-96-8) is a protected derivative of L-pyro glutamic acid, commonly used in organic synthesis, particularly for peptide synthesis and pharmaceutical intermediate production. It exists as a white to off-white solid, with a Boc (tert-butyloxycarbonyl) protecting group on the nitrogen and a methyl ester, which increases its solubility in organic solvents.

Chemical Properties

Synonyms: Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate, N-Boc-L-pyro glutamic acid methyl ester, (S)-Methyl-N-Boc-pyro glutamate, Boc-Pyr-OMe, 1-(tert-butyl) 2-methyl (S)-5-oxopyrrolidine-1,2-dicarboxylate.

Molecular Formula: C11H17NO5

Molecular Weight: 243.26 g/ mol.

Appearance: White to off-white powder or crystal

Melting Point: 68−73∘C

Solubility: Soluble in organic solvents (e.g., dichloromethane).

Storage Temperature: 2-8°C

 

Uses and Applications

Peptide Synthesis: It is frequently used as a building block for the N-terminal pyro glutamylation of peptides, providing protection against amino peptidases. The Boc group allows for selective deprotection.

Pharmaceutical Intermediates: Used in the synthesis of specialized APIs (Active Pharmaceutical Ingredients), particularly antibiotics and other complex peptide therapeutics.

Chiral Building Block: Employed in the synthesis of biologically active compounds and unnatural amino acids (e.g., Proline – templated glutamic acid).

Cosmetics and Skincare: Used in the development of personal care products, often acting as a specialized component.

Flavoring and Fragrance Agents: Used as an intermediate in the production of unique scent and flavor compounds.

Handling and Stability

Stability: Stable under standard laboratory conditions.

Hazard Identification: The substance is typically classified with hazard codes related to skin/eye irritation and, depending on the supplier, can be labeled with toxic (Xn) and environmental (N) danger signs.

Precautions: Avoid exposure to air, moisture, and excessive heat.

 

 

FAQs

What is Boc-L-Pyroglutamic Acid Methyl Ester?

It is a protected amino acid derivative used in peptide synthesis, where the Boc group protects the amine functionality during reactions.

What is the CAS number of Boc-L-Pyroglutamic Acid Methyl Ester?

The CAS number is 108963-96-8, used for accurate identification of the compound.

What are the main applications of this compound?
It is commonly used in peptide synthesis, pharmaceutical research, and the development of active pharmaceutical ingredients (APIs).
How should this chemical be stored?

Store it in a cool, dry, and well-ventilated area in tightly sealed containers away from moisture.

Is this product suitable for research use?

Yes, it is widely used in research laboratories and industrial R&D applications.