2,4-Dichloro-6-methylpyrimidine (CAS 5424-21-5) is a white-to-light yellow crystalline solid with the molecular formula 𝐶5𝐻4𝐶𝑙2𝑁2. It is primarily used as a key intermediate in organic synthesis, particularly for developing pharmaceutical compounds and agrochemicals. It is known to undergo reactions like double cross-coupling.

Key Properties

CAS Number: 5424-21-5

Molecular Formula: 𝐶5𝐻4𝐶𝑙2𝑁2

Molecular Weight: 163.00 g/mol

Appearance: White to pale yellow solid/crystalline

Melting Point: 44-47°C

Density: ∼1.396g/cm3

Boiling Point: 105°C/22 mmHg

Solubility: Soluble in common organic solvents.

Storage: Recommended storage in a cool, dark place (often <15∘C).

Synonyms

2,4-Dichloro-6-methylpyrimidine

Pyrimidine, 2,4-dichloro-6-methyl-

6-Methyl-2,4-dichloropyrimidine

2,6-Dichloro-4-methylpyrimidine

NSC 13199

Uses and Applications

Chemical Intermediate: It serves as a building block in the synthesis of more complex pyrimidine derivatives.

Pharmaceutical Development: Used in the preparation of bioactive compounds and inhibitors.

Organic Synthesis: It acts as a reagent in cross-coupling reactions, such as those with tributylstannylpyridine, to produce, for example, 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines.

Fluorous Synthesis: Used as a scaffold in the preparation of substituted pyrimidines through reactions with thiols.

Agrochemicals: Similar to other chlorinated pyrimidines, it can be used for manufacturing agricultural chemicals.

Handling

It is generally recommended to keep it in a cool, dark, and well-ventilated area.