1149-26-4

N-Benzyloxycarbonyl-L-valine CASNO:1149-26-4

Chemical Properties and Identification

CAS Number: 1149-26-4

Molecular Formula: C13H17NO4

Molecular Weight: 251.28 g/mol

Appearance: White to almost white powder or crystal

Melting Point: 59–64 °C (lit.)

Assay/Purity: Typically $\ge$99% (Neutralization titration)

Solubility: Sparingly soluble in water (approx. 16% at 20°C); soluable in methanol

Synonyms:

N-(Benzyloxycarbonyl)-L-valine,

N-Cbz-L-valine,

Z-Val-OH,

(S)-2-[(Benzyloxycarbonyl)amino]-3-methylbutanoic acid

 

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Uses and Applications

Pharmaceutical Intermediate: Primarily used in the production of APIs (Active Pharmaceutical Ingredients), specifically anti-infective drugs like Valacyclovir and Valganciclovir.

Peptide Synthesis: Used as an N-protected amino acid building block in both solution and solid-phase peptide synthesis (SPPS).

Protecting Group Chemistry: The Benzyloxycarbonyl (CBZ) group is used to protect the amino group of L-valine to prevent unwanted reactions during synthesis.

Storage and Handling

Storage: Store in a cool, dry, and well-ventilated area, preferably at or below 15°C.

Stability: Stable under normal temperatures and pressures.

Safety: While relatively low in toxicity, it may cause skin and eye irritation. Use appropriate protective equipment (dust mask, gloves, safety glasses).

CBZ-L-Valine (CAS 1149-26-4) is a protected amino acid derivative used primarily in the pharmaceutical and peptide synthesis industries. It is commonly used as an intermediate for producing antiviral medications such as Valacyclovir and Valganciclovir.

 

What is N-Benzyloxycarbonyl-L-valine (Cbz-L-Valine)?
N-Benzyloxycarbonyl-L-valine, also known as Cbz-L-Valine or Z-Val-OH, is an N-protected L-valine derivative widely used as an intermediate in peptide synthesis and pharmaceutical research
What is the CAS number of N-Benzyloxycarbonyl-L-valine?
The CAS number of N-Benzyloxycarbonyl-L-valine is 1149-26-4.
What are the applications of N-Benzyloxycarbonyl-L-valine?
It is commonly used in peptide synthesis, amino acid protection, pharmaceutical intermediate manufacturing, fine chemical production, and academic research laboratories.
Why is the Cbz protecting group used in peptide synthesis?
The Cbz (Benzyloxycarbonyl) group protects the amino functionality during multi-step synthesis, enabling selective reactions and improving the efficiency of peptide production.
What is the molecular formula of N-Benzyloxycarbonyl-L-valine?

The molecular formula is C₁₃H₁₇NO₄, and its molecular weight is 251.28 g/mol.

FAQs

What is N-Benzyloxycarbonyl-L-valine (Cbz-L-Valine)?
N-Benzyloxycarbonyl-L-valine, also known as Cbz-L-Valine or Z-Val-OH, is an N-protected L-valine derivative widely used as an intermediate in peptide synthesis and pharmaceutical research
What is the CAS number of N-Benzyloxycarbonyl-L-valine?
The CAS number of N-Benzyloxycarbonyl-L-valine is 1149-26-4.
What are the applications of N-Benzyloxycarbonyl-L-valine?
It is commonly used in peptide synthesis, amino acid protection, pharmaceutical intermediate manufacturing, fine chemical production, and academic research laboratories.
Why is the Cbz protecting group used in peptide synthesis?
The Cbz (Benzyloxycarbonyl) group protects the amino functionality during multi-step synthesis, enabling selective reactions and improving the efficiency of peptide production.
What is the molecular formula of N-Benzyloxycarbonyl-L-valine?

The molecular formula is C₁₃H₁₇NO₄, and its molecular weight is 251.28 g/mol.

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