Primary Synonyms and Alternative Names:
- 2-Methoxy-5-bromopyridine
- 2-Methyloxy-5-bromopyridine
- 3-Bromo-6-methoxypyridine
- Pyridine, 5-bromo-2-methoxy-
- 5-Bromo-2-methoxypyr
- 2-Methoxy-5-pyridyl bromide
5-Bromo-2-methoxypyridine (CAS 13472-85-0) is a crucial halogenated pyridine building block used extensively in pharmaceutical research and organic synthesis. It acts as a key intermediate for synthesizing αvβ3 antagonists, somatostatin sst3 receptor antagonists, and anti-HIV integrase inhibitors, while also serving as a ligand for central nervous system receptors.
Uses and Applications
- Pharmaceutical Intermediates: It is a vital building block in the synthesis of specialized drug candidates, including αvβ3 antagonists and somatostatin sst3 receptor antagonists.
- Anti-HIV Drug Development: It is used as a synthetic tool in developing novel integrase inhibitors, which are crucial for combating HIV by preventing viral DNA integration.
- Neuroscience Research: It functions as a ligand for central nicotinic acetylcholine receptors, helping to study their roles and develop treatments for neurological disorders.
- Organic Synthesis: As a functionalized pyridine (halogenated hydrocarbon), it is used as a versatile building block for creating complex chemical structures.
- Agrochemical Advancement: Similar to other pyridine derivatives, it has potential applications in producing agrochemicals like insecticides or herbicides.
Safety: It is known to cause serious eye irritation, skin irritation, and respiratory irritation.
The CAS number is 13472-85-0. It is used in the synthesis of APIs, agrochemicals, and specialty chemical compounds. Its bromine group allows for cross-coupling reactions, making it versatile for creating complex molecules. It is typically supplied in high purity grades such as ≥98% or ≥99% depending on application needs. Store in a cool, dry, well-ventilated area in tightly sealed containers away from heat and moisture.
