2-Amino-2-methylpropionitrile (CAS 19355-69-2) is a colorless to pale yellow liquid, 𝐶4𝐻8𝑁2, functioning as a versatile intermediate in pharmaceutical and organic synthesis. Often used to produce heterocyclic compounds, it is a key building block in API synthesis for neurology and oncology, typically requiring storage at 2-8°C.

Key Properties

CAS Number: 19355-69-2

Molecular Formula: 𝐶4𝐻8𝑁2

Molecular Weight: 84.12 g/mol

Appearance: Colorless to pale yellow liquid (or oil)

Boiling Point: ≈150.4±23.0°Cat 760 mmHg

Density: ≈0.9 g/cm3

Flash Point: ≈44.7

Properties: Hygroscopic, moderate volatility, mild ammonia-like odor

Storage: 2-8°C

Synonyms

2-Amino-2-methylpropanenitrile

2-Cyanoisopropylamine

Aminodimethylacetonitrile

2-Aminopropane-2-carbonitrile

1-Cyano-1-methylethylamine

2-Amino-2-cyanopropane

Uses and Applications

Pharmaceutical Intermediates: Primarily used in the synthesis of active pharmaceutical ingredients (APIs), particularly for oncology, cardiovascular, and neurology treatments.

Organic Synthesis: Acts as a building block for producing heterocyclic compounds.

Agrochemicals: Used in the production of specialized crop protection agents.

Research: Utilized as a specialized reagent in chemical research.

Safety and Handling

Hazard Identification: May be fatal if inhaled, causes serious eye damage and skin irritation, and is harmful in contact with skin.

Reactivity: Sensitive to moisture.

Production: Can be synthesized from the reaction of acetone and potassium cyanide (usually to produce the hydrochloride salt)