619-42-1

Methyl 4-Bromobenzoate CASNO:619-42-1

Physical properties:

Methyl 4-bromobenzoate (CAS 619-42-1) Is an organic compound, specifically an aromatic ester derived from 4-bromobenzoic acid, commonly used as a building block in chemical synthesis and pharmaceutical research. It typically appears as a white to nearly white crystalline solid.

CAS Number: 619-42-1

Molecular Formula: 𝐶8𝐻7𝐵𝑟𝑂2

Molecular Weight: 215.04 g/mol

Physical State: White to almost white crystals or powder

Melting Point: 79.5°C to 81°C (approximate range)

Solubility: Soluble in common organic solvents like ethanol and diethyl ether; low solubility in water

Structure: Para-substituted aryl bromide (almost planar)

Synonyms

4-Bromobenzoic acid methyl ester

Methyl p-bromobenzoate

1-Bromo-4-(methoxycarbonyl)benzene

4-Methoxycarbonylphenyl bromide

p-Bromobenzoic acid methyl ester

Benzoic acid, 4-bromo-, methyl ester 

 

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Uses and Applications

Methyl 4-bromobenzoate is widely used as a reagent in organic synthesis, particularly for forming new carbon-carbon bonds due to the presence of the reactive bromine atom.

  • Pharmaceutical Intermediates: Used in the synthesis of antifolate drugs, such as pemetrexed.
  • Chemical Synthesis Building Block: Serves as a starting material in the preparation of three-carbon-bridged 5-substituted furo[2, 3-d]pyrimidine and 6-substituted pyrrolo[2, 3-d]pyrimidine analogs.
  • Cross-Coupling Reactions: Used to prepare compounds like methyl 4-(2-pyridyl)benzoate via cross-coupling with organometallic compounds.
  • Radioiodination: Employed in the preparation of stable radioiodinating reagents to label monoclonal antibodies for cancer radiotherapy.
  • Environmental Research: Used in studies to stimulate the microbial dechlorination of PCBs (polychlorinated biphenyls).

Safety

  • Hazards: Identified as an irritant; contact may cause skin, eye, and respiratory irritation.
  • Handling: Should be handled with appropriate laboratory precautions in a well-ventilated area

 

What is Methyl 4-Bromobenzoate?
Methyl 4-Bromobenzoate is an organic compound commonly used as an intermediate in chemical synthesis, especially in pharmaceutical and research applications.
What is the CAS number of Methyl 4-Bromobenzoate?

The CAS number is 619-42-1, which uniquely identifies this chemical compound.

What are the main uses of Methyl 4-Bromobenzoate?
It is mainly used in organic synthesis, pharmaceutical manufacturing, agrochemical production, and laboratory research.
What is the molecular formula of Methyl 4-Bromobenzoate?

The molecular formula is C₈H₇BrO₂.

Is Methyl 4-Bromobenzoate safe to handle?
It should be handled with proper safety precautions, including protective equipment and following safety guidelines, as it may cause irritation.
How should Methyl 4-Bromobenzoate be stored?
Store in a cool, dry place away from direct sunlight and incompatible substances, in tightly sealed containers.

FAQs

What is Methyl 4-Bromobenzoate?
Methyl 4-Bromobenzoate is an organic compound commonly used as an intermediate in chemical synthesis, especially in pharmaceutical and research applications.
What is the CAS number of Methyl 4-Bromobenzoate?

The CAS number is 619-42-1, which uniquely identifies this chemical compound.

What are the main uses of Methyl 4-Bromobenzoate?
It is mainly used in organic synthesis, pharmaceutical manufacturing, agrochemical production, and laboratory research.
What is the molecular formula of Methyl 4-Bromobenzoate?

The molecular formula is C₈H₇BrO₂.

Is Methyl 4-Bromobenzoate safe to handle?
It should be handled with proper safety precautions, including protective equipment and following safety guidelines, as it may cause irritation.
How should Methyl 4-Bromobenzoate be stored?
Store in a cool, dry place away from direct sunlight and incompatible substances, in tightly sealed containers.

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