2,4-Dichloro-5-Nitro Pyrimidine (CAS 49845-33-2)

Physical properties:

  • Molecular Formula : C4HCl2N3O2
  • Molecular Weight   :98g/mol
  • Appearance : Yellow solid or clear yellow liquid/low-melting solid
  • Melting Point : 28-32∘C
  • Boiling Point :9∘Cat 0.5mmHg or 135∘C at 17Torr
  • Density :74g/cm3 at 20∘C
  • Solubility : Slightly soluble in water (1.0 g/L at 25 °C), chloroform, and methanol
  • Sensitivity : Moisture and heat sensitive; typically stored under an inert gas

 

Uses:

  • Pharmaceuticals: Synthesizes antiviral, antibacterial, and anticancer agents, potentially blocking cell growth by inhibiting Epidermal Growth Factor (EGF) receptors in cancer cells.
  • Agrochemicals: A key precursor for herbicides, helping to improve crop yields.
  • Material Science: Used in developing advanced polymers and coatings for better durability and chemical resistance.
  • Research: Serves as a valuable “building block” for creating diverse heterocyclic compounds, including those for medicinal chemistry and drug discovery.
  • Reactive Sites: The two chlorine atoms and the nitro group offer multiple points for chemical reactions, allowing for complex modifications.
  • Versatile Scaffold: Its pyrimidine structure is fundamental in many biologically active compounds, making it a sought-after intermediate.

 

Key Applications:

  • Pharmaceutical Synthesis:
    • Intermediate for antiviral, antibacterial, and anticancer agents, including kinase inhibitors.
    • Used in solid-phase synthesis of diaminopurines.
  • Agricultural Chemistry:
    • Key intermediate for synthesizing various herbicides to control weeds.
  • Material Science:
    • Component in creating specialty polymers and protective coatings for enhanced durability.
  • Research & Development:
    • A fundamental heterocyclic building block for organic synthesis.
    • Used in environmental studies for pollutant degradation research.
    • Employed as an analytical standard in complex mixture analysis.
  • Reactive Sites: The two chlorine atoms and the nitro group on the pyrimidine ring are susceptible to nucleophilic substitution, allowing chemists to introduce various functional groups.
  • Versatility: Its structure enables the creation of diverse, biologically active compounds with potential uses across multiple fields.

In essence, it’s a valuable starting material for creating more complex, high-value chemicals for human health, crop protection, and advanced materials.

 

 

 

 

FAQs

What is 2,4-Dichloro-5-Nitropyrimidine (CAS 49845-33-2)?
2,4-Dichloro-5-Nitropyrimidine is a substituted pyrimidine compound used as a key intermediate in pharmaceutical and fine chemical synthesis.
What are the applications of 2,4-Dichloro-5-Nitropyrimidine?
It is widely used in the synthesis of pyrimidine-based APIs, pharmaceutical intermediates, and medicinal chemistry research compounds.
Is 2,4-Dichloro-5-Nitropyrimidine used in pharmaceutical manufacturing?

Yes, it is commonly used in pharmaceutical and API research for developing active compounds and advanced intermediates.

Do you manufacture 2,4-Dichloro-5-Nitropyrimidine in bulk quantities?
Yes, we manufacture and supply 2,4-Dichloro-5-Nitropyrimidine (CAS 49845-33-2) in bulk and commercial quantities.
What purity grades are available for this product?
The product is available in high-purity grades suitable for pharmaceutical, laboratory, and specialty chemical applications.

FAQs

What is 2,4-Dichloro-5-Nitropyrimidine (CAS 49845-33-2)?
2,4-Dichloro-5-Nitropyrimidine is a substituted pyrimidine compound used as a key intermediate in pharmaceutical and fine chemical synthesis.
What are the applications of 2,4-Dichloro-5-Nitropyrimidine?
It is widely used in the synthesis of pyrimidine-based APIs, pharmaceutical intermediates, and medicinal chemistry research compounds.
Is 2,4-Dichloro-5-Nitropyrimidine used in pharmaceutical manufacturing?

Yes, it is commonly used in pharmaceutical and API research for developing active compounds and advanced intermediates.

Do you manufacture 2,4-Dichloro-5-Nitropyrimidine in bulk quantities?
Yes, we manufacture and supply 2,4-Dichloro-5-Nitropyrimidine (CAS 49845-33-2) in bulk and commercial quantities.
What purity grades are available for this product?
The product is available in high-purity grades suitable for pharmaceutical, laboratory, and specialty chemical applications.