Physical properties:

p-Toluenesulfonamide (CAS 70-55-3) is a white, crystalline solid (𝐶7𝐻9𝑁𝑂2𝑆) used primarily as a plasticizer and chemical intermediate for pharmaceuticals, resins, and dyes. It features a melting point of approximately 133-137∘C and has moderate water solubility, with higher solubility in organic solvents like alcohol and acetone.

Key Properties and Technical Data:

• Molecular Formula: 𝐶7𝐻9𝑁𝑂2𝑆
• Molecular Weight: 171.21 g/mol
• Appearance: White crystalline powder/solid
• Melting Point: 133–137∘C (lit.)
• Boiling Point: ∼220–222∘Cat 13 hPa (under vacuum)
• Solubility: Moderate in water; soluble in organic solvents (ethanol, acetone)
• Purity: Commonly available in > 98% or 99% purity
• CAS Number: 70-55-3

Common Applications:

• Synthesis Intermediate: Used in the synthesis of sulfonamide drugs and pharmaceuticals.
• Plasticizer: Serves as a reactive plasticizer for polymers, synthetic resins, and plastics.
• Chemical Synthesis: Employed in the production of dyes and as a reagent in organic synthesis.

Handling and Storage:

• Storage: Should be stored in a cool, dark place, typically below 15^∘ C.
• Safety: Potential skin and eye irritant.

p-Toluenesulfonamide (CAS 70-55-3) is an organic compound (𝐶7𝐻9𝑁𝑂2𝑆) primarily used as a plasticizer and chemical intermediate. It is commonly known by synonyms including 4-methylbenzenesulfonamide, p-tosylamide, tosylamide, and 4-toluenesulfonamide. It often appears in technical literature as Gliclazide impurity A or Tolbutamide impurity A.

Key Synonyms for p-Toluenesulfonamide (CAS 70-55-3):

• Systematic/Chemical Names:4-Methylbenzenesulfonamide, 4-Toluenesulfonamide, 4-Methylbenzene-1-sulfonamide, 𝑝-Tolylsulfonamide, Toluene-4-sulfonamide, 4-Tolylsulphonamide, Toluene-p-sulfonamide.
• Common/Abbreviated Names:PASAM, Tosylamide, 𝑝-Tosylamide, 𝑝 –Toluene sulphonamide, 𝑝-Toluenesulfonamide (PTSamide), 𝑝-Toluenesulfonic acid amide, 4-Toluenesulfonylamide.
• Trade/Industry Names:PTS100, Topcizer 1S.
• Impurity Designations:Gliclazide EP Impurity A, Tolbutamide Impurity A.
• Other Identifiers:NSC 9908, EINECS 200-741-1, MFCD00011692.

The compound is a white solid, often used as a reactive plasticizer for polymers and in the synthesis of pharmaceuticals.

p-Toluenesulfonamide (CAS 70-55-3) is a white, crystalline organic compound primarily used as an intermediate in chemical synthesis, a plasticizer for resins, and in manufacturing dyes and pharmaceuticals. It acts as a curing agent for epoxy resins, a monomer in polymers, a fungicide/mildewcide in coatings, and a brightener in nickel plating.

Key Uses and Applications:

• Chemical Intermediate: It is a key building block in the production of specialized chemicals, including toluene-based plasticizers and sulfonamide drugs (e.g., sulfathiazole, sulfamethoxazole).
• Polymer and Resin Industry: Used as a modifying agent to enhance the mechanical properties and durability of epoxy resins, thermoplastics, and thermosetting materials.
• Coatings and Adhesives: Acts as a stabilizer and curing agent to improve adhesive bonding properties and thermal stability in coating formulations.
• Pharmaceutical and Agriculture: Serves as a raw material in synthesis and as a potential intermediate for agrochemicals.
• Dyes and Pigments: Utilized as a raw material in the manufacturing of pigments, inks, and dyes.
• Other Applications: Employed as an intermediate for producing saccharin, an antistatic agent for polyamides, and a brightener in electroplating baths.

It is important to note that p-toluenesulfonamide can be used in combination with o-toluenesulfonamide as a plasticizer for coatings, commonly referred to as o/p-toluene sulfonamide or OPTSA