57260-73-8

N-Boc-Ethylenediamiine CASNO:57260-73-8

Physical properties:

N-Boc-Ethylenediamine (CAS 57260-73-8) is a colorless to light yellow oily liquid or low-melting solid (đ¶7đ»16 𝑁2𝑂2, 𝑀𝑊=160.22) used as a mono-protected diamine for chemical synthesis. Key properties include a boiling point of 72–80 °C at 0.1 mmHg, 1.012 g/mL density, and high reactivity. It is typically stored under inert atmosphere at 2-8 °C.

Key Properties and Specifications

Appearance: Clear, colorless to light yellow oily liquid or liquid-solid mixture.

Melting Point: Reportedly 68–70 °C, though often liquid at room temperature.

Boiling Point: 72–80 °C at 0.1 mmHg; 105 °C at 20 mmHg.

Density: 1.012 g/mL at 20 °C.

Refractive Index: 𝑛20/đ·=1.458.

Flash Point: 113°C (235°F).

Solubility: Soluble in common organic solvents (e.g., dichloromethane, methanol).

Stability: Air-sensitive; requires storage under inert gas (nitrogen/argon) at 2−8°C.

Hazards: Harmful if swallowed, inhaled, or absorbed through skin.

Common Applications

Pharmaceutical Intermediate: Utilized in the synthesis of peptide derivatives and drug candidates.

Surface Modification: Used to introduce amino groups onto functionalized surfaces.

Bifunctional Spacer: The Boc group allows selective protection of one amine, enabling targeted chemical reactions at the free terminal amino group.

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Identifiers

CAS Number: 57260-73-8

Molecular Formula:Â đ¶7đ»16 𝑁2𝑂2

Molecular Weight: 160.22 g/mol

Synonyms: tert-Butyl (2-aminoethyl)carbamate, 𝑁-(tert-Butoxycarbonyl)-1,2-diaminoethane

N-Boc-Ethylenediamine (CAS 57260-73-8) is primarily known as tert-butyl N-(2-aminoethyl) carbamate or N-Boc-1,2-diaminoethane. It is a chemical intermediate used in organic synthesis, including the preparation of pharmaceuticals and amino-functionalized molecules.

Common Synonyms for 57260-73-8:

  • tert-Butyl N-(2-aminoethyl)carbamate
  • N-Boc-1,2-diaminoethane
  • N-(2-Aminoethyl)carbamic acid tert-butyl ester
  • 2-(N-tert-Butoxycarbonylamino)ethylamine
  • N-(tert-Butoxycarbonyl)-1,2-diaminoethane
  • tert-Butyl (2-aminoethyl)carbamate
  • n-boc-ethane-1,2-diamine

N-Boc-Ethylenediamine (CAS 57260-73-8) is a mono-protected diamine widely used as a versatile building block in organic synthesis, pharmaceutical research, and bio conjugation. It is essential for introducing ethylenediamine units while avoiding side reactions, commonly serving in the synthesis of pharmaceuticals, peptides, and functionalized materials.

Key Uses and Applications:

  • Pharmaceutical Intermediate:Used in the development of drugs targeting cardiovascular and neurological diseases. It is also involved in the synthesis of thyronamine derivatives.
  • Bio conjugate Chemistry:Functions as a linker to attach imaging agents or drugs to biomolecules.
  • Peptide Synthesis:Serves as a protected building block in the synthesis of peptide hormones like LHRH.
  • Chemical Synthesis:Acts as a key intermediate for preparing compounds such as (2-isothiocyanato-ethyl)-carbamic acid tert-butyl ester.
  • Functionalized Polymers:Used to create tailored polymers for applications in coatings and adhesives.
  • Antimicrobial Studies:Acts as a building block for developing antimicrobial compounds.

It is frequently preferred in chemical laboratories as a protecting agent, where the tert-butoxycarbonyl (Boc) group helps protect one amine group, allowing for the selective modification

What is N-Boc-Ethylenediamine?
N-Boc-Ethylenediamine is a Boc-protected diamine compound commonly used as an intermediate in chemical synthesis
What is the CAS number of N-Boc-Ethylenediamine?

The CAS number is 57260-73-8, which uniquely identifies this compound.

What are the main uses of N-Boc-Ethylenediamine?

It is widely used in pharmaceutical synthesis, peptide chemistry, and organic reactions as a building block.

What is the molecular formula of N-Boc-Ethylenediamine?

Its molecular formula is C7H16N2O2.

Is N-Boc-Ethylenediamine hazardous?

It may cause irritation on contact or inhalation, so proper lab safety precautions are recommended.

How should N-Boc-Ethylenediamine be stored?

Store it in a cool, dry place, tightly sealed, and away from moisture and heat.

FAQs

What is N-Boc-Ethylenediamine?
N-Boc-Ethylenediamine is a Boc-protected diamine compound commonly used as an intermediate in chemical synthesis
What is the CAS number of N-Boc-Ethylenediamine?

The CAS number is 57260-73-8, which uniquely identifies this compound.

What are the main uses of N-Boc-Ethylenediamine?

It is widely used in pharmaceutical synthesis, peptide chemistry, and organic reactions as a building block.

What is the molecular formula of N-Boc-Ethylenediamine?

Its molecular formula is C7H16N2O2.

Is N-Boc-Ethylenediamine hazardous?

It may cause irritation on contact or inhalation, so proper lab safety precautions are recommended.

How should N-Boc-Ethylenediamine be stored?

Store it in a cool, dry place, tightly sealed, and away from moisture and heat.

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