3153-37-5

Methyl 4-Chlorobutyrate CASNO:3153-37-5

Physical Properties:

Methyl 4-chlorobutyrate (CAS 3153-37-5) is a colorless to pale yellow liquid with the formula 

𝐶𝑙𝐶𝐻2𝐶𝐻2𝐶𝐻2𝐶𝑂𝑂𝐶𝐻3. It is primarily used as a pharmaceutical intermediate for producing active ingredients, particularly with antiviral and antifungal properties. Key properties include a molecular weight of 136.58, a boiling point of 175–176 °C, and a density of 1.12 g/mL.

Physical and Chemical Properties

Molecular Formula: 𝐶5𝐻9𝐶𝑙𝑂2

Molecular Weight: 136.58 g/mol

Boiling Point: 175–176 °C (lit.)

Density: 1.12 g/mL at 25 °C (lit.)

Refractive Index: 𝑛20/𝐷 1.433 (lit.)

Appearance: Liquid

Solubility: Slightly soluble in water

Assay: ≥98%

 

Category:

Safety and Handling

  • Hazard Class: Class 3 (Flammable liquid)
  • Storage: Keep in a cool, dark place, ideally below 15°C.
  • Hazard Statements: H226 (Flammable liquid and vapour), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation).
  • Precautionary Statements: P210 (Keep away from heat), P280 (Wear protective gloves/clothing/eye protection).

Methyl 4-chlorobutyrate (CAS 3153-37-5) is a colorless, combustible liquid (𝐶5𝐻9𝐶𝑙𝑂2) mainly used in pharmaceuticals and synthesis. Key synonyms include Methyl 4-chlorobutanoate, 4-Chlorobutyric acid methyl ester, and Methyl 𝛾-chlorobutyrate. It has a boiling point of 175-176∘C and acts as an important intermediate for chemical production. 

Synonyms and Identifiers

  • Methyl 4-chlorobutanoate
  • 4-Chlorobutyric acid methyl ester
  • Methyl 𝛾-chlorobutyrate (or Methyl gamma-chlorobutyrate)
  • Methyl omega-chlorobutyrate
  • Butanoic acid, 4-chloro-, methyl ester
  • ClCH22(CH22)$_2𝐶(𝑂)𝑂𝐶𝐻_3$
  • CAS Number: 3153-37-5
  • EC Number: 221-592-9
  • MDL Number: MFCD00001003
  • PubChem CID: 76612

Methyl 4-chlorobutyrate (CAS 3153-37-5) is a versatile, colorless chemical intermediate primarily used to synthesize pharmaceuticals (such as Prasugrel for blood clotting), agrochemicals, and fine chemicals. It acts as a building block for complex organic molecules, allowing the introduction of functional groups via nucleophilic substitution.

Key Uses and Applications:

  • Pharmaceutical Intermediate:Used in the production of Active Pharmaceutical Ingredients (APIs) for cardiovascular treatment, antiviral, antibacterial, and antifungal medications.
  • Chemical Synthesis:Acts as a key building block in organic chemistry due to its reactivity in nucleophilic substitution, ester hydrolysis, and Grignard reactions.
  • Agrochemicals:Utilized in the development and manufacturing of agricultural chemicals.
  • Specialty Chemical Manufacturing:Employed in producing fine chemicals and potentially in fragrance applications.
  • Laboratory Reagent:Used in research for constructing carbon chains and new compound development.

 

 

FAQs

What is Methyl 4-Chlorobutyrate (CAS 3153-37-5)?
Methyl 4-Chlorobutyrate is an organic compound used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.
What are the main applications of Methyl 4-Chlorobutyrate?
It is primarily used in drug synthesis, chemical research, and as a building block for complex organic molecules.
Is Methyl 4-Chlorobutyrate suitable for industrial use?
Yes, it is widely used in industrial applications due to its high purity, stability, and reliable chemical properties.
How should Methyl 4-Chlorobutyrate be stored?

It should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and moisture to maintain stability.

What industries use Methyl 4-Chlorobutyrate?
Industries such as pharmaceuticals, agrochemicals, and specialty chemical manufacturing frequently use this compound.

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