Ethyl-2-Chloro Acetoacetate (CAS609-15-4)

Other Properties:

• Vapor Pressure: ~49.4-100 Pa at 20 °C
• Physical State: Liquid at room temperature

Key Uses:

• Pharmaceuticals: Intermediate for synthesizing active ingredients in drugs like Cimetidine, Cinepazet, barbiturates, antimalarials, and compounds with potential anticancer or anti-inflammatory properties.
• Agrochemicals: Used to make pesticides (like Mevinphos) and herbicide-safeners
• Heterocyclic Chemistry: A versatile reagent for creating rings like thiazoles, pyrazoles, and oxazoles, which are common in drug structures, say BOC Sciences and Wacker Chemie AG.
• Analytical Standards: Used as a reference standard for method development, validation (AMV), and quality control (QC) in drug manufacturing, according to ClLaboratories and AquigenBio.
• Biochemical Research: Studied for its role in enzymatic dehalogenation by glutathione in yeast.

Chemical Role:

• Building Block: Its chloroacetyl group and ester functionality make it highly reactive for nucleophilic substitution and enolate chemistry, explain GlobalLinker and Wacker Chemie AG.

Pharmaceutical Applications:

• Synthesis of APIs: Used to build complex structures for active pharmaceutical ingredients (APIs).
• Drug Development: A precursor for agonists targeting PPARδ receptors and for novel anticancer agents (dimethylimidazothiadiazolecarbohydrazides).
• Reference Standard: Essential for method validation and quality control in drug manufacturing (e.g., for Abbreviated New Drug Applications – ANDA).

Chemical & Research Uses:

• Organic Synthesis: A key building block in organic chemistry for creating esters, ketones, and heterocyclic compounds.
• Reagent: Utilized as a reagent in general chemical research.
• Antimicrobial Research: Shows activity against bacteria like Staphylococcus aureus and E. coli, making it relevant in antimicrobial studies.

Other Industries:

• Agrochemicals: Serves as an intermediate in the production of agricultural chemicals.
• Specialty Chemicals: Employed in the creation of various high-value, specialized chemicals.

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