Cbz-L-Valine methyl ester CASNO:24210-19-3

Chemical Properties 

CAS Number: 1149-26-4

Molecular Formula: C13H17NO4

Molecular Weight: 251.28 g/mol

Appearance: White to almost white powder or crystal

Melting Point: 59–64 °C (lit.)

Assay/Purity: Typically $\ge$99% (Neutralization titration)

Solubility: Sparingly soluble in water (approx. 16% at 20°C); soluable in methanol

Synonyms:

N-(Benzyloxycarbonyl)-L-valine,

N-Cbz-L-valine,

Z-Val-OH,

(S)-2-[(Benzyloxycarbonyl)amino]-3-methylbutanoic acid

 

Uses and Applications

Pharmaceutical Intermediate: Primarily used in the production of APIs (Active Pharmaceutical Ingredients), specifically anti-infective drugs like Valacyclovir and Valganciclovir.

Peptide Synthesis: Used as an N-protected amino acid building block in both solution and solid-phase peptide synthesis (SPPS).

Protecting Group Chemistry: The Benzyloxycarbonyl (CBZ) group is used to protect the amino group of L-valine to prevent unwanted reactions during synthesis.

Storage and Handling

Storage: Store in a cool, dry, and well-ventilated area, preferably at or below 15°C.

Stability: Stable under normal temperatures and pressures.

Safety: While relatively low in toxicity, it may cause skin and eye irritation. Use appropriate protective equipment (dust mask, gloves, safety glasses).

CBZ-L-Valine (CAS 1149-26-4) is a protected amino acid derivative used primarily in the pharmaceutical and peptide synthesis industries. It is commonly used as an intermediate for producing antiviral medications such as Valacyclovir and Valganciclovir.

 

What is Cbz-L-Valine Methyl Ester used for?

It is used as a protected amino acid derivative in peptide synthesis and pharmaceutical research.

What does CAS No: 24210-19-3 indicate?

It is the unique chemical identification number assigned to Cbz-L-Valine Methyl Ester.

What is the role of the Cbz group in this compound?

The Cbz (carbobenzyloxy) group protects the amino group during synthesis reactions.

Is Cbz-L-Valine Methyl Ester suitable for industrial applications?

Yes, it is widely used in pharmaceutical, biotech, and chemical industries.

What are the advantages of using this compound in synthesis?

It offers stability, controlled reactivity, and efficient peptide bond formation.

FAQs

What is Cbz-L-Valine Methyl Ester used for?

It is used as a protected amino acid derivative in peptide synthesis and pharmaceutical research.

What does CAS No: 24210-19-3 indicate?

It is the unique chemical identification number assigned to Cbz-L-Valine Methyl Ester.

What is the role of the Cbz group in this compound?

The Cbz (carbobenzyloxy) group protects the amino group during synthesis reactions.

Is Cbz-L-Valine Methyl Ester suitable for industrial applications?

Yes, it is widely used in pharmaceutical, biotech, and chemical industries.

What are the advantages of using this compound in synthesis?

It offers stability, controlled reactivity, and efficient peptide bond formation.