Cbz-Glycine Ethyl Ester CASNO:1145-81-9

Chemical Properties (CAS 1145-81-9)

CAS Number: 1145-81-9

Molecular Formula: 𝐶12𝐻15𝑁𝑂4

Molecular Weight: 237.25 g/mol

Appearance: White to off-white crystalline powder

Melting Point: 80-85 °C (often cited as 81-82°C)

Solubility: Soluble in organic solvents such as alcohols, ethers, and chlorinated hydrocarbons (e.g., DMF, DMSO, ethanol)

Density: ~1.162 g/cm³

Boiling Point: ~376.3 °C (predicted)

Storage: 2-8°C recommended

Synonyms

Z-Gly-OEt (or Z-Glycine ethyl ester)

Ethyl N-[(benzyloxy)carbonyl]glycinate

N-Cbz-glycine ethyl ester

N-Benzyloxycarbonylglycine ethyl ester

Ethyl Z-glycinate

Glycine, N-[(phenylmethoxy)carbonyl]-, ethyl ester

Cbz-Glycine Ethyl Ester (CAS 1145-81-9) is a protected amino acid derivative primarily used in organic synthesis and peptide synthesis. It features a benzyloxycarbonyl (Cbz or Z) group protecting the amino group and an ethyl ester protecting the carboxyl group of glycine, making it a valuable building block in pharmaceutical development.

 

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Uses and Applications

Cbz-Glycine ethyl ester is widely utilized as a protected intermediate in chemical and pharmaceutical industries:

Peptide Synthesis: Used as a protected glycine building block, allowing for selective peptide coupling reactions without interfering with functional groups.

Pharmaceutical Intermediates: Serves as a raw material for synthesizing Active Pharmaceutical Ingredients (APIs), including peptide-based drugs.

Organic Chemistry: Employed as a stable, protected amino acid in organic synthesis reactions to build complex molecular structures.

Agrochemical Development: Utilized in the synthesis of specialized pesticides or biostimulants.

Safety and Handling

  • Toxicity: Generally considered to have some toxicity; avoid direct contact with skin and eyes.
  • Handling: Use appropriate personal protective equipment (gloves, goggles, lab coat) and handle in a well-ventilated area.
  • Storage: Keep in a dry, cool, well-ventilated place, sealed at room temperature or 2-8°C.

 

 

What is Cbz-Glycine Ethyl Ester?

Cbz-Glycine Ethyl Ester is an N-protected glycine derivative commonly used as an intermediate in peptide synthesis and organic chemistry.

What is the CAS number of Cbz-Glycine Ethyl Ester?

The CAS number is 1145-81-9.

What are the primary uses of Cbz-Glycine Ethyl Ester?

It is widely used in peptide synthesis, pharmaceutical intermediates, and research applications.

What does the Cbz group do in this compound?

The Cbz (Carbobenzyloxy) group protects the amino function, allowing controlled reactions during synthesis.

Is Cbz-Glycine Ethyl Ester used in drug development?

Yes, it serves as a building block in the development of peptides and pharmaceutical compounds.

FAQs

What is Cbz-Glycine Ethyl Ester?

Cbz-Glycine Ethyl Ester is an N-protected glycine derivative commonly used as an intermediate in peptide synthesis and organic chemistry.

What is the CAS number of Cbz-Glycine Ethyl Ester?

The CAS number is 1145-81-9.

What are the primary uses of Cbz-Glycine Ethyl Ester?

It is widely used in peptide synthesis, pharmaceutical intermediates, and research applications.

What does the Cbz group do in this compound?

The Cbz (Carbobenzyloxy) group protects the amino function, allowing controlled reactions during synthesis.

Is Cbz-Glycine Ethyl Ester used in drug development?

Yes, it serves as a building block in the development of peptides and pharmaceutical compounds.