Boc Glycine is an N-protected amino acid where glycine is protected with a tert-butyloxycarbonyl (Boc) group. The CAS number is 4530-20-5, which uniquely identifies this compound. It is widely used in peptide synthesis, pharmaceutical research, and organic chemistry as a building block. Its molecular formula is C7H13NO4. It is generally considered low hazard but should be handled with standard laboratory safety precautions. Store it in a cool, dry place, tightly sealed, and away from moisture and direct sunlight.What is Boc Glycine?What is the CAS number of Boc Glycine?What are the main uses of Boc Glycine?What is the molecular formula of Boc Glycine?Is Boc Glycine hazardous?How should Boc Glycine be stored?
Boc glycine CASNO:4530-20-5
Boc-glycine (CAS 4530-20-5), often abbreviated as Boc-Gly-OH, is an N-protected amino acid derivative extensively used in peptide synthesis and biochemical research. The tert-butyloxycarbonyl (Boc) group acts as a protective shield for the amino group, allowing for selective peptide bond formation.
- Chemical Properties (CAS 4530-20-5)
- Formula: 𝐶7𝐻13𝑁𝑂4
- Molecular Weight: 175.18 g/mol
- Appearance: White to almost white powder or crystal
- Melting Point: 86–89 °C
- Solubility: Soluble in organic solvents (e.g., dichloromethane, methanol), and alkali solution; insoluble in water
- Stability: Stable under normal temperatures; deprotected under mild acidic conditions
- Structure: (𝐶𝐻3)3𝐶𝑂𝐶𝑂𝑁𝐻𝐶𝐻2𝐶𝑂2𝐻
Synonyms
N-(tert-Butoxycarbonyl)glycine
N-Boc-glycine
Boc-Gly-OH
(tert-Butoxycarbonyl)aminoacetic acid
N-tert-Butyloxycarbonylglycine
2-[(2-Methylpropan-2-yl)oxycarbonylamino]acetic acid
NSC 127669
Uses and Applications
Boc-glycine is primarily used as a key building block in chemical synthesis:
- Peptide Synthesis: Used as a protected amino acid in solid-phase peptide synthesis (SPPS) and liquid-phase synthesis for introducing glycine residues.
- Pharmaceutical Intermediate: Utilized in the composition of drugs, including anti-inflammatory agents containing ketoprofen and sodium hyaluronate.
- Biochemical Research: Employed for the synthesis of tripeptides (e.g., H-Gly-Pro-Glu-OH), which are analogs of neuroprotective drugs.
- Chemical Reactions: Acts as a promoter for the allylation of hydrazones and isatin.
- HIV Inhibitor Studies: Research indicates potential application in HIV research due to its ability to bind to CD4 and gp120 proteins.
- HPLC Reference: Used as a reference compound in high-performance liquid chromatography.
- Safety Information
- Hazard Statements: Irritating to eyes, respiratory system, and skin.
- Combustibility: Combustible solid that burns, but propagates flame with difficulty. It can form explosive mixtures with air when finely divided.
- Storage: Keep in a dark, dry, and sealed place at room temperature.
FAQs
What is Boc Glycine?
Boc Glycine is an N-protected amino acid where glycine is protected with a tert-butyloxycarbonyl (Boc) group.
What is the CAS number of Boc Glycine?
The CAS number is 4530-20-5, which uniquely identifies this compound.
What are the main uses of Boc Glycine?
It is widely used in peptide synthesis, pharmaceutical research, and organic chemistry as a building block.
What is the molecular formula of Boc Glycine?
Its molecular formula is C7H13NO4.
Is Boc Glycine hazardous?
It is generally considered low hazard but should be handled with standard laboratory safety precautions.
How should Boc Glycine be stored?
Store it in a cool, dry place, tightly sealed, and away from moisture and direct sunlight.
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