6-Methyl-2-Thiouracil CASNO:56-04-2

Physical properties:

Molecular Formula: C5H6N2OS
Molecular Weight: 142.18
Physical State: Crystalline powder
Melting Point: 330°C
Density: 1.36 g/cm3
Solubility: Insoluble in water
Flash Point: 160.8°C
Odor: Onion-like.

Synonyms:

6-Methyl-2-thiouracil (primary chemical name)
Methylthiouracil (INN name)
4-Hydroxy-2-mercapto-6-methylpyrimidine
2-Mercapto-4-methyl-6-hydroxypyrimidine
6-Methyl-2-mercaptouracil
2-Thio-6-methyluracil
4(1H)-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo-
6-Methyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
Methiocil
MTU

Uses:

Medical/Pharmaceutical: Used to treat hyperthyroidism (overactive thyroid) by reducing thyroid hormone production.
Pre-surgical Treatment: Applied in the preparation of patients for thyroid surgery, particularly for reducing thyroid storm risks.
Chemical Intermediate: Serves as a building block for synthesizing compounds, including anti-HIV agents (S-DABOs) and cardiovascular drugs like dipyridamole.
Research: Used in biochemical studies involving thyroid hormone metabolism and as a reagent in the synthesis of luminescent gold(I) thiouracilate complexes

Key Applications:

Medical and Pharmaceutical Uses (Antithyroid Agent)
Treatment of Hyperthyroidism: It is used as a medication to treat hyperthyroidism (overactive thyroid) and Graves’ disease.
Thyroid Regulation: It functions by reducing the synthesis of thyroid hormones in the thyroid gland.
Preoperative Preparation: Used in the preparation of patients for thyroid surgery and to treat thyroid storm.
2. Research and Laboratory Applications
Analytical Standard: It is used in high-performance liquid chromatography (HPLC) and gas chromatography (GC) as an analytical standard for detecting thyreostatic residues in veterinary and human samples.
Nitric Oxide Synthase Inhibitor: Used as a competitive inhibitor of Nitric Oxide Synthase (NOS) in research studies.
Biochemical Research: Employed to induce hypothyroidism in animal models to study adrenal and gonadal functions.
3. Chemical Synthesis and Industrial Applications
Anti-HIV Agents: Used in the synthesis of

(S-DABOs) based anti-HIV agents.
Histone Deacetylase Inhibitors: Used in the synthesis of uracil-containing histone deacetylase inhibitors for medical research.
Luminescent Materials: Used in the synthesis of luminescent gold(I) thiouracilate complexes.
Agriculture: Used to facilitate the study of plant growth, specifically to stimulate flowering and fruiting.

 

What is 6-Methyl-2-Thiouracil (CAS No: 56-04-2)?
6-Methyl-2-Thiouracil is a sulfur-containing organic compound commonly used as a pharmaceutical intermediate and in biochemical research.
What are the applications of 6-Methyl-2-Thiouracil?
It is primarily used in pharmaceutical synthesis, laboratory research, and as a precursor in the development of antithyroid drugs.
What is the chemical formula of 6-Methyl-2-Thiouracil?
The chemical formula of 6-Methyl-2-Thiouracil is C5H6N2OS.
Is 6-Methyl-2-Thiouracil safe to handle?
It should be handled with proper safety precautions, including protective equipment, as it may cause irritation if inhaled or contacted with skin.
What is the purity level of 6-Methyl-2-Thiouracil available in the market?
The compound is typically available in high purity (≥98% or higher), depending on the supplier and intended use.
 

FAQs

What is 6-Methyl-2-Thiouracil (CAS No: 56-04-2)?
6-Methyl-2-Thiouracil is a sulfur-containing organic compound commonly used as a pharmaceutical intermediate and in biochemical research.
What are the applications of 6-Methyl-2-Thiouracil?
It is primarily used in pharmaceutical synthesis, laboratory research, and as a precursor in the development of antithyroid drugs.
What is the chemical formula of 6-Methyl-2-Thiouracil?
The chemical formula of 6-Methyl-2-Thiouracil is C5H6N2OS.
Is 6-Methyl-2-Thiouracil safe to handle?
It should be handled with proper safety precautions, including protective equipment, as it may cause irritation if inhaled or contacted with skin.
What is the purity level of 6-Methyl-2-Thiouracil available in the market?
The compound is typically available in high purity (≥98% or higher), depending on the supplier and intended use.