Description: 4-Bromobutyronitrile, with the Chemical Abstracts Service (CAS) number 5332-06-9, is a bifunctional organic compound featuring both a nitrile (-C≡N) and a primary alkyl bromide group. This structure makes it a valuable and versatile intermediate in organic synthesis. The presence of a terminal bromine atom provides a reactive site for nucleophilic substitution, while the nitrile group can undergo various transformations, including hydrolysis to carboxylic acids or reduction to amines. These properties make it a key building block in the synthesis of pharmaceuticals, agrochemicals, and other complex organic molecules. This document provides a comprehensive technical overview of its properties, spectral characteristics, reactivity, and safe handling procedures.
Key Applications
- Pharmaceutical Synthesis: It serves as a precursor for various pharmaceutical agents. For instance, its derivative, 4-bromo-2,2-diphenylbutyronitrile, is a key intermediate in the synthesis of the antidiarrheal medication loperamide
- Cyclopropane Derivatives: A significant application is its use in the synthesis of cyclopropyl cyanide through intramolecular cyclization. Cyclopropyl cyanide is an important intermediate for various compounds, including the anticoagulant drug prasugrel.
- General Organic Synthesis: It is used to introduce a three-carbon nitrile-containing chain (cyanopropyl group) into molecules, which can be further elaborated into amines, carboxylic acids, and other functional groups.
FAQs Yes, it is widely used in pharmaceutical and API research as a reactive building block. Yes, we manufacture and supply 4-Bromobutyronitrile (CAS 5332-06-9) in bulk and commercial quantities.
