2-Methoxy Ethoxy Methyl Chloride(MEM-Chloride) CASNO: 3970-21-6
2-Methoxyethoxymethyl chloride (MEM-Chloride, CAS 3970-21-6) is a colorless liquid (𝐶4𝐻9𝐶𝑙𝑂2) acting as a robust protecting reagent in organic synthesis, particularly for alcohols to form MEM ethers. It is highly valued for being selectively cleaved under aprotic conditions, offering superior stability compared to MOM chloride.
Key Properties
Appearance: Colorless to light yellow liquid.
Molecular Formula: 𝐶4𝐻9𝐶𝑙𝑂2.
Molecular Weight: 124.56g/mol.
Density: 1.091g/mL
Boiling Point: 50–52°C.
Flash Point: 54°C
Solubility: Reacts with water.
Stability: Moisture-sensitive, requires storage under inert gas (e.g., 2–8°C).
Synonyms
1-(Chloromethoxy)-2-methoxyethane
MEM-Cl, MEM-Chloride
Ethylene glycol chloromethyl methyl ether
Key Uses and Applications
Organic Synthesis: Primarily used to introduce the methoxyethoxy methyl (MEM) group for protecting hydroxyl (OH) groups during complex, multi-step synthesis.
Pharmaceutical Development: Employed in the synthesis of pharmaceuticals, such as the side chain of roxithromycin.
Specialty Chemicals: Used in synthesizing and refining chemical intermediates.
Polymer Chemistry: Utilized in research for developing specialized coatings, adhesives, and polymers.
Hazards
- Signal Word: Danger.
- Hazard Statements: Flammable liquid
FAQs
It is an organic reagent widely used as a protecting group agent in organic synthesis, especially for alcohols.
The CAS number is 3970-21-6, which uniquely identifies this compound.
It is commonly used in pharmaceutical synthesis, organic chemistry reactions, and research laboratories.
Store it in a cool, dry place, tightly sealed, and away from moisture and incompatible substances.
Yes, it is widely used in R&D and industrial chemical synthesis processes.
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