2-chloro-5-nitro benzoic acid (CAS 2516-96-3)

Physical properties:

 

  • Appearance: White to light yellow, pale cream, or beige-brown crystalline powder or solid.
  • Molecular Formula: ๐‚๐Ÿ•๐‡๐Ÿ’๐‚๐ฅ๐๐Ž๐Ÿ’
  • Molecular Weight: ๐Ÿ๐ŸŽ๐Ÿ.๐Ÿ“๐Ÿ” g/mol.
  • Melting Point: The melting point is generally reported in the range of ๐Ÿ๐Ÿ”๐Ÿ’โ€“๐Ÿ๐Ÿ”๐Ÿ– ยฐC.
  • Boiling Point: Predicted to be approximately ๐Ÿ‘๐Ÿ“๐Ÿ”.๐Ÿ“ยฑ๐Ÿ๐Ÿ•.๐ŸŽ ยฐC.
  • Density: The relative density is about ๐Ÿ.๐Ÿ” g/cm๐Ÿ‘.
  • Solubility: It is slightly soluble in water (approximately 3.6 g/L), but is soluble in various organic solvents such as ethanol, ethyl acetate, methanol, and N,N-dimethylformamide.
  • pKa: The pKa is approximately ๐Ÿ.๐Ÿ๐Ÿ• at ๐Ÿ๐Ÿ“ยฐC
  • Synonyms:
  • 6-Chloro-3-nitrobenzoic acid
  • 5-Nitro-2-chlorobenzoic acid
  • Benzoic acid, 2-chloro-5-nitro-
  • Mesalamine Impurity M (EP/BP)
  • Mesalamine Impurity 3
  • 2,5-CNBA

 

Category:

Uses:

  • Pharmaceuticals:ย An intermediate in the synthesis of various drugs, including some anti-diarrheal agents, notes Arvee Laboratories.
  • Agrochemicals:ย Used in the production of crop protection chemicals, according to Arvee Laboratories.
  • Organic Synthesis:ย Acts as a reagent for creating other complex organic compounds, where the chloro and nitro groups can be modified.
  • Research & Development:ย Explored for creating novel materials, such as luminescent coordination polymers with europium (Eu(III)).
  • Analytical Standards:ย Used as a reference standard for identifying impurities, such as Mesalazine Impurity M, in pharmaceutical quality control.
  • Reactivity:ย The presence of the carboxylic acid group, chlorine atom, and nitro group allows for diverse chemical transformations, making it a valuable building block.
  • Functional Groups:ย The nitro group can be reduced or substituted, and the chlorine atom can undergo displacement, enabling the creation of various derivatives.

 

Key Applications & Uses:

  • Pharmaceuticals:ย An intermediate for APIs, contributing to analgesic, anti-inflammatory, and other drug development.
  • Agrochemicals:ย Used in creating pesticide molecules.
  • Dyes & Pigments:ย A precursor for various colorants.
  • Material Science:ย Acts as a linker for building materials like Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs).
  • Organic Synthesis:ย A key reagent for synthesizing complex organic compounds, allowing for transformations like converting the carboxyl group to acid chlorides, esters, or amides, and substituting the chlorine atom.
  • Carboxyl Group:ย Can be converted into acid chlorides, esters, and amides.
  • Chlorine Atom:ย Can undergo substitution reactions.
  • Nitro Group:ย Can be reduced or substituted to alter aromatic structure for different properties.

 

FAQs

What is 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3)?

2-Chloro-5-Nitrobenzoic Acid is a substituted aromatic acid used as an important intermediate in pharmaceutical and fine chemical synthesis.

What are the applications of 2-Chloro-5-Nitrobenzoic Acid?

It is widely used in the synthesis of pharmaceutical intermediates, agrochemicals, dyes, and specialty chemical products.

Is 2-Chloro-5-Nitrobenzoic Acid used in pharmaceutical manufacturing?
Yes, it is commonly used in pharmaceutical and API research for developing advanced intermediates and active compounds
Do you manufacture 2-Chloro-5-Nitrobenzoic Acid in bulk quantities?
Yes, we manufacture and supply 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3) in bulk and commercial quantities.
What purity grades are available for this product?
The product is available in high-purity grades suitable for pharmaceutical, laboratory, and industrial applications.
Is 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3) available for export?

Yes, it is supplied for domestic and international markets with complete regulatory and export documentation.

FAQs

What is 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3)?

2-Chloro-5-Nitrobenzoic Acid is a substituted aromatic acid used as an important intermediate in pharmaceutical and fine chemical synthesis.

What are the applications of 2-Chloro-5-Nitrobenzoic Acid?

It is widely used in the synthesis of pharmaceutical intermediates, agrochemicals, dyes, and specialty chemical products.

Is 2-Chloro-5-Nitrobenzoic Acid used in pharmaceutical manufacturing?
Yes, it is commonly used in pharmaceutical and API research for developing advanced intermediates and active compounds
Do you manufacture 2-Chloro-5-Nitrobenzoic Acid in bulk quantities?
Yes, we manufacture and supply 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3) in bulk and commercial quantities.
What purity grades are available for this product?
The product is available in high-purity grades suitable for pharmaceutical, laboratory, and industrial applications.
Is 2-Chloro-5-Nitrobenzoic Acid (CAS 2516-96-3) available for export?

Yes, it is supplied for domestic and international markets with complete regulatory and export documentation.