2-Amino-5-Bromo Pyridine CASNO: 1072-97-5..

Physical  Properties
Appearance: White to almost white powder or crystalline solid (prisms).
Molecular Formula: 𝐂𝟖𝐇𝟕𝐍𝐎𝟒
Molecular Weight: 𝟏𝟖𝟏.𝟏𝟓g/mol.
Melting Point: 219-225°C
Boiling Point: 340°Cat 760 mmHg (approximate value).
Density: 1.392g/cm³.
Solubility in Water: Very slightly soluble or insoluble, <0.1g/100 mL at 22°C
.pKa: 2.26±0.10(predicted).
Flash Point: 153.4°C

Synonyms:
▪ 2-Nitro-m-toluic Acid
▪ Benzoic acid, 3-methyl-2-nitro-
▪ m-Toluic acid, 2-nitro-
▪ 2-Nitro-3-methylbenzoic acid
▪ Niraparib Impurity 10

Uses:
Pharmaceuticals: Intermediate in creating new drugs, including potential anti-inflammatory and antibacterial agents, and precursors for complex heterocyclic structures like benzodiazepines and quinazolines.
Agrochemicals:2-Amino-5-Bromo Pyridine CASNO: 1072-97-5, Used in synthesizing pesticides, with research also focusing on its role in breaking down certain pesticides in wastewater.Dyes & Materials: Employed in the production of reactive dyes, polyester compounds, and in materials science for developing organic ligands and non-linear optical (NLO) materials.
Organic Synthesis: A valuable building block for researchers due to its functional groups (nitro and carboxylic acid), allowing for various reactions like reduction, esterification, and amidation to create complex organic molecules.
Wastewater Treatment: Investigated for its potential as an oxidation catalyst, particularly for degrading pollutants like chlorantraniliprole and reducing chloride levels.
It’s a nitroaromatic carboxylic acid, combining properties of both acid and nitro groups.
Its structure allows for diverse chemical transformations, making it a key precursor in advanced synthetic chemistry.

Key Applications:

Pharmaceutical Intermediates: 2-Amino-5-Bromo Pyridine CASNO: 1072-97-5,Used in the development of Active Pharmaceutical Ingredients (APIs), specifically for:
Synthesizing antineoplastic agents like Niraparib.
Creating anti-inflammatory and analgesic drugs.
Developing novel Indolin-2-one derivatives that act as protein tyrosine phosphatase 1B inhibitors.
Serving as a precursor for sulfonamide antibiotics and kinase inhibitors used in oncology.
Organic Synthesis: Acts as a key intermediate for creating complex heterocyclic systems. It is frequently used to:

Synthesize 2,3-unsubstituted indoles and quinazoline scaffolds.
Undergo nitro group reduction to produce functionalized aniline derivatives.
Serve as a building block for esterification and amidation reactions.
Agrochemicals: Utilized as a building block for the synthesis of herbicides and pesticides.
Wastewater Treatment: Investigated as an oxidation catalyst effective against pollutants like chlorantraniliprole. It also exhibits photocatalytic activity under visible light when combined with titanium dioxide.

Dyes and Pigments: Used in the production of azo dyes and other coloring agents for the textile and manufacturing industries.
Analytical Chemistry: Serves as a standard in chromatographic techniques to measure and analyze compounds in complex mixtures.
 Materials Science: Used to develop organic ligands and nonlinear optical (NLO) materials.