About This Product:
CAS Number : 1071-46-1
Molecular Weight : 132.12
Molecular Formula : C5H8O4
Synonym(s) :MONOETHYL MALONATE; Monoethyl malonic acid;
3-ethoxy-3-oxopropanoate; 3-ethoxy-3-oxapropanoic acid;
3-ethoxy-3-oxo-propanoic acid; hydrogen maL;Malonic acid 1-ethyl;
Ethyl hydrogen malonate
Physical Properties:
Appearance : Colorless to pale yellow color liquid
Purity : >90.00% (GC)
Melting Point : -13°C
Boiling Point : 106.5°C at 3 mmHg
Storage Temperature : Room temperature
Conditions to avoid : Moisture sensitive
LOD : NA
Solubility : Chloroform
Density : 1.119 g/mL
Moisture content : 0.50 %
Ethyl Hydrogen Malonate (MEM) CAS 1071-46-1 ,It’s used in organic synthesis, particularly in the malonic ester synthesis, to create pharmaceuticals, agrochemicals, and other chemicals. Monoethyl malonate serves as a valuable intermediate in the synthesis of various organic compounds.
It is a key reactant in the malonic ester synthesis, a method for preparing substituted acetic acids.
It is used to synthesize compounds found in pharmaceuticals, agrochemicals, fragrances, and other organic products.
Key Uses & Applications:
- Pharmaceuticals:Intermediate for synthesizing drugs, potentially for prion diseases, and as a catalyst in some preparations, including radioactive tracers.
- Agrochemicals:A building block for creating various pesticides and other crop protection chemicals.
Organic Synthesis:- Malonic Ester Synthesis:Key in forming substituted acetic acids.
- Acylation Agent:Used to introduce acyl groups.
- Knoevenagel Condensation: Reacts with aldehydes to form new carbon-carbon bonds.
- Dieckmann Ring Closure: Precursor for tetramic acids.
- Material Science: Used in the creation of advanced materials like organic light-emitting diodes (OLEDs) and perovskite solar cells.
- Fragrance Industry: Serves as a precursor for esters and aromatic compounds.
Applications:
- Preparation of Tetramic Acids:Used in the synthesis of tetramic acids via Dieckmann ring closure.
- Condensation and Acylation Reactions:Acts as a reactant in Knoevenagel condensation with aldehydes and in various acylation reactions (acting as an acylation agent).
- Pharmaceutical Intermediate:Utilized in the synthesis of indole glyoxylamides for potential Prion disease treatments.
- Organocatalysis:Used in organocatalytic decarboxylative Doebner-Knoevenagel reactions.
- Biochemical Research:Applied in the conjugation to amino-modified oligonucleotides.
- Chemical Synthesis:Involved in the preparation of gamma-lactones from olefins via intermolecular carbolactonization with Mn(III) acetate.
