About This Product:
CAS Number : 870-46-2
Molecular Weight : 132.16
Molecular Formula : C5H12N2O2
Synonym(s) : Hydrazinecarboxylic acid;
1,1-Dimethylethyl ester;
(Tert-Butoxycarbonyl ) hydrazine
tert-Butoxycarbonylhydrazine
Carbazic Acid tert-Butyl Ester
Physical Properties:
Appearance : White waxy solid
Purity : >98.00% (GC)
Melting Point : 39°C – 42°C
Boiling Point : NA
Storage Temperature : Keep in dark place 2 to 8°C
LOD : NA
Solubility : Soluble in Methanol, MDC
Density : 1.2023
Moisture content : NMT 1.00 %
Boc-Hydrazide (Tert-Butyl Carbazate) CAS 870-46-2, It is a hydrazine derivative with a tert-butyl protective group, used as a stable intermediate in organic synthesis, particularly in the pharmaceutical industry. It appears as a solid or liquid, is soluble in organic solvents like ethanol and acetone, and serves to protect amino groups in peptide synthesis and as a building block for creating hydrazone and other protected nitrogenous intermediates.
Key Uses:
- Pharmaceuticals: A key building block for Active Pharmaceutical Ingredients (APIs), used in synthesizing drugs like Vandetanib and HIV protease inhibitors.
- Peptide Synthesis: Employed in solid-phase peptide synthesis and for determining the optical purity of alpha-amino aldehydes.
- Organic Synthesis: Acts as a protecting group (Boc) for amines and other functionalities, allowing selective reactions in multi-step syntheses.
- Agrochemicals & Dyes: Used as an intermediate in the production of various agrochemicals, dyes, and pigments.
- Analytical Chemistry: Can react with creatinine to help study enzyme activity or kidney function.
- Hydrazone Formation: Condenses with aldehydes to form hydrazones, useful intermediates in various syntheses.
Key Applications:
- Pharmaceuticals:
Intermediate in synthesizing Active Pharmaceutical Ingredients (APIs).
Building block for HIV-1 protease inhibitors.
Used in creating drugs like Vandetanib (an anticancer drug).
Research tool for enzyme inhibitors in cancer, diabetes, and neurological disorders.
- Peptide Synthesis:
Protects amino groups during peptide chain formation, ensuring purity and stability.
- Organic Synthesis:
Forms hydrazones by reacting with aldehydes, serving as intermediates.
Used in palladium-catalyzed cross-coupling reactions.
Precursor for synthesizing sulfonic and carboxylic hydrazides.
- Analytical Chemistry:
Used in determining the optical purity of α-amino aldehydes.
Reacts with creatinine to study enzyme activity or kidney function.
- Agrochemicals & Dyes:
Serves as a key intermediate in their manufacture.
