6-Methyl Uracil CAS NO: 626-48-2

6-Methyluracil (CAS 626-48-2) is a white, crystalline solid and pyrimidone derivative (formula 𝐶5𝐻6𝑁2𝑂2) used primarily as a pharmaceutical intermediate and biochemical research tool. It acts as an antimetabolite inhibiting protein synthesis, with key applications in drug development and organic synthesis. It is moderately toxic, with high-temperature decomposition.

Properties

CAS Number: 626-48-2

Molecular Weight: 126.11 g/mol

Appearance: Fine grayish-white crystalline powder

Melting Point: 318 °C (dec.)

Solubility: Soluble in water (7 g/L at 22 ºC)

Density: 1.226 g/cm³

Flash Point: 208ºC

Synonyms

• 6-Methylpyrimidine-2,4(1H,3H)-dione
• 6-Methyl-2,4(1H,3H)-pyrimidinedione
• 2,4-Dihydroxy-6-methylpyrimidine
• Pseudothymine

Uses and Applications

Pharmaceutical Industry: Used as a key intermediate in the development of new drugs, specifically acting as an antimetabolite.

Chemical Research: Used to study the behavior and reactions of pyrimidone derivatives.

Organic Synthesis: Serves as a building block for creating a wide range of molecules.

Material Science: Employed in the design of new materials, potentially enhancing stability or reactivity in applications like electronics.

Hazards and Safety

Toxicity: Moderately toxic if ingested.

Reproductive Effects: Experimental reproductive, neoplastigenic, and teratogenic data.

Safety Handling: Suspected of damaging fertility or the unborn child.

Decomposition: Emits toxic fumes of 𝑁𝑂𝑥 when heated to decomposition.