N-Boc-D-Serine Methyl Ester (CAS 95715-85-8) is a protected amino acid derivative (𝐶9𝐻17𝑁𝑂5) primarily used in peptide synthesis. It is a white to off-white solid, typically with a purity of

Key Properties and Specifications

CAS Number: 95715-85-8

Molecular Formula: 𝐶9𝐻17𝑁𝑂5

Molecular Weight: 219.24 g/mol

Physical State: Solid

Melting Point: 215∘C(at 760 mmHg)

Density: 1.08g/mL at 25∘C

Refractive Index: 1.453

Optical Rotation:  [𝛼]25/𝐷+18.8∘(𝑐=5 in methanol)

Storage: Stable under standard conditions; typically stored at room temperature or in a cool, dry place.

Applications and Usage

Peptide Synthesis: Used as a building block for introducing D-Serine into peptides, with the Boc group allowing for selective deprotection.

Chemical Research: Acts as a common reagent in organic synthesis and medicinal chemistry.

Chiral Intermediate: Used for creating chiral molecules due to the known stereochemistry of the D-Serine derivative.

Safety and Handling

• Handling: Standard laboratory safety procedures should be followed, as it is used in chemical synthesis.
• Safety Data: The substance is generally considered stable, but it is important to avoid incompatible products.

N-Boc-D-Serine Methyl Ester (CAS 95715-85-8) is a protected amino acid derivative commonly used in peptide synthesis. Its primary synonyms include Boc-D-Ser-OMe, N-(tert-Butoxycarbonyl)-D-serine methyl ester, and N-Boc-(D)-Serine methyl ester. The compound acts as a building block for D-serine residues in drug development and neuroscience research.

Key Synonyms and Identifiers:

Boc-D-Ser-OMe

N-(tert-Butoxycarbonyl)-D-serine methyl ester

N-Boc-(D)-Serine methyl ester

N-[(1,1-Dimethylethoxy)carbonyl]-D-serine methyl ester

Methyl (2R)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoate

tert-Butyl [(R)-1-(methoxycarbonyl)-2-hydroxyethyl]carbamate

Boc-D-β-hydroxyalanine methyl ester

(R)-Methyl 2-(tert-butoxycarbonylamino)-3-hydroxypropanoate

This compound is utilized in research for incorporating D-serine into peptides, particularly for studying NMDA receptor co-agonism.

N-Boc-D-Serine Methyl Ester (CAS 95715-85-8) is a protected amino acid derivative primarily used as a building block in peptide synthesis and pharmaceutical development. It features a tert-butoxycarbonyl (Boc) group for amine protection, making it essential for incorporating D-serine into chiral molecules, drugs, and organic synthesis.

Key Uses and Applications:

• Peptide Synthesis: It serves as a, building block for synthesizing peptides that require the inclusion of D-serine, which can enhance the metabolic stability of the final compound.
• Pharmaceutical Development: Used in research for developing chiral catalysts and in the synthesis of pharmaceutical intermediates.
• Organic Synthesis: Acts as an amino acid derivative for modifying or building complex, optically active molecules.
• Biochemical Research: Utilized as a reagent in biochemical research related to amino acid derivatives and peptide chemistry.

The compound is commonly utilized due to its purity (often >98%) and the versatility of the Boc protecting group in multi-step organic reactions.