Physical Properties:

CAS Number: 10314-98-4

Appearance: White to almost white powder/crystals

Formula Weight: 263.29 g/mol

Molecular Formula: C₁₄H₁₇NO₄

Melting Point: 71-75⁰C

Boiling Point: 443.9 ⁰C +/- 45⁰C at 760 mmHg

Density (Predicted): 1.265 g/cm³

Solubility: Soluble in methanol

Storage: Recommended storage at room temperature

1-Cbz-isonipecotic acid (CAS 10314-98-4), Is a protected amino acid used in organic synthesis, commonly known as 1-benzyloxycarbonyl-4-piperidinecarboxylic acid, 1-carbobenzoxyisonipecotic acid, or Z-isonipecotic acid. It is often used to produce pharmaceuticals and bioactive molecules, particularly in peptide synthesis.

Synonyms:

1-Benzyloxycarbonyl-4-piperidinecarboxylic acid

1-Carbobenzoxyisonipecotic acid

N-Cbz-4-piperidinecarboxylic acid

1-Cbz-4-piperidinecarboxylic acid

1-Cbz-isonipecotic acid

Z-Isonipecotic acid

Piperidine-1,4-dicarboxylic acid 1-benzyl ester

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

Other Identifiers:

MDL Number: MFCD01568759

Molecular Formula: C₁₄H₁₇NO₄

Molecular Weight: 263.29 g/mol

1-Cbz-isonipecotic acid (CAS 10314-98-4) is a protected amino acid derivative used primarily as a building block in organic synthesis and pharmaceutical drug development. It serves as a key intermediate for creating piperidine-based bioactive molecules, including analgesics and HDAC inhibitors, and is used to protect amine groups during chemical reactions.

Uses:

Pharmaceutical Intermediate: Used in the development of new drugs, specifically in designing compounds that interact with biological targets.

Organic Synthesis: Acts as a reagent to introduce protected piperidine-4-carboxylic acid units into molecules.

Peptide Synthesis: Employed in solid-phase peptide synthesis for enhanced stability and yield.

Chemical Research: Used in the synthesis of heterocyclic compounds and as a specialized chemical intermediate.

It is also known as 1-Carbobenzoxy-4-piperidinecarboxylic acid or N-Benzyloxycarbonyl-isonipecotic acid.