Physical properties:

Molecular Formula: C9H17NO5

Molecular Weight: 219.25

Appearance: Liquid or low-melting solid (light yellow)

Density: 1.082 G/Ml AT 25°

Flash Point: 113°C

Refractive Index: n20/D 1.452

Boiling Point: 354.3 ± 32°C at 760mmHg

Melting Point: 42°C

Solubility: Soluble in methanol

Optical Rotation:  -18° to -20° (c=5 in MeOH)

Storage: 2-8°C

Synonyms:

Boc-Ser-OMe (most common abbreviation)

N-Boc-L-serine Methyl Ester

Boc-L-serine methyl ester

Methyl N-(tert-butoxycarbonyl)-L-serinate

N-tert-Butyloxycarbonyl-L-serine methyl ester

(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Boc-L-β-hydroxyalanine methyl ester

Uses:

• Peptide Synthesis: It is most commonly used in Boc solid-phase peptide synthesis. The Boc (tert-butyloxycarbonyl) group protects the amino group, while the methyl ester protects the carboxylic acid, allowing chemists to selectively build complex peptide chains.
• Pharmaceutical Research: It serves as a precursor or intermediate in drug discovery, used to develop bioactive compounds and new therapeutics.
• Biochemical Tools: Researchers use it to prepare specific biological markers like the Tn antigenand L-glutamic acid p-nitroanilide analogs.
• Material Science: It is used in the creation of new biomedical polymersthat feature serine and threonine side groups.
• Bioconjugation and Protein Engineering: It helps attach biomolecules to drugs or imaging agents and is used to modify proteins to improve their stability or activity.

Key Applications:

• Peptide Synthesis: Serves as a versatile building block, often used in solid-phase peptide synthesis (SPPS) and for preparing protected amino acids.

• Drug Development:Used in the development of new therapeutics and for synthesizing specialized compounds like Tn antigens and L-glutamic acid p-nitroanilide analogs.

• Bioconjugation: Employed to attach biomolecules to drugs or imaging agents to improve efficacy and targeting.
• Protein Engineering: Utilized in the modification of proteins to introduce specific functionalities that improve stability and activity.
• Analytical Chemistry: Used in research applications for the identification and separation of complex mixtures.