2,4-Dichloro-5-fluoropyrimidine CAS NO: 2927-71-1

2,4-Dichloro-5-fluoropyrimidine (CAS 2927-71-1) is a high-purity (typically 98%+) white-to-yellow solid, C4HCl2FN2, with a melting point of 37-41∘C. It is a versatile pharmaceutical intermediate used primarily in synthesizing anticancer agents, 5-fluorouracil derivatives, and kinase inhibitors. It acts as a key reagent for nucleophilic substitutions in medicinal and fine chemical applications.

Key Properties and Identification

CAS Number: 2927-71-1

Physical State: White to Yellow Solid or Solid/Liquid Mixture

Storage: Refrigerated (0-10∘C), under inert gas (nitrogen or argon)

InChI Key: WHPFEQUEHBULBW-UHFFFAOYSA-N

Synonyms

• 2,4-Dichloro-5-fluoropyrimidine
• 5-Fluoro-2,4-dichloropyrimidine

Uses and Applications

Pharmaceutical Intermediate: Used in the synthesis of anticancer drugs.

5-Fluorouracil Derivatives: Key in producing glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.Kinase Inhibitors: Starting material for 5-fluoropyrimidine-2-carboxamides, 5-fluoropyrimidine-4-carboxamides, and 2,4-diamino-5-fluoropyrimidine derivatives.

Chemical Synthesis: Used for building complex molecular frameworks via Suzuki coupling, such as creating 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine.

Fine Chemicals: Contributes to the synthesis of specialized agrochemicals and electronic materials.

Safety and Handling

Hazard Identification: Causes severe skin burns and eye damage (Danger).

Handling: Harmful if swallowed. Requires protective clothing, gloves, and eye protection.

Storage Condition: Store in an inert atmosphere at 2-8∘C