3-Methyl-2-Nitro benzoic acid (CAS 5437-38-7)

Uses:

• Pharmaceuticals: Intermediate in creating new drugs, including potential anti-inflammatory and antibacterial agents, and precursors for complex heterocyclic structures like benzodiazepines and quinazolines.
• Agrochemicals: Used in synthesizing pesticides, with research also focusing on its role in breaking down certain pesticides in wastewater.
• Dyes & Materials: Employed in the production of reactive dyes, polyester compounds, and in materials science for developing organic ligands and non-linear optical (NLO) materials.
• Organic Synthesis: A valuable building block for researchers due to its functional groups (nitro and carboxylic acid), allowing for various reactions like reduction, esterification, and amidation to create complex organic molecules.
• Wastewater Treatment: Investigated for its potential as an oxidation catalyst, particularly for degrading pollutants like chlorantraniliprole and reducing chloride levels.
• It’s a nitroaromatic carboxylic acid, combining properties of both acid and nitro groups.
• Its structure allows for diverse chemical transformations, making it a key precursor in advanced synthetic chemistry.

Key Applications:

Pharmaceutical Intermediates: Used in the development of Active Pharmaceutical Ingredients (APIs), specifically for:

Synthesizing antineoplastic agents like Niraparib.

Creating anti-inflammatory and analgesic drugs.

Developing novel Indolin-2-one derivatives that act as protein tyrosine phosphatase 1B inhibitors.

Serving as a precursor for sulfonamide antibiotics and kinase inhibitors used in oncology.

Organic Synthesis: Acts as a key intermediate for creating complex heterocyclic systems. It is frequently used to:

• Synthesize 2,3-unsubstituted indolesand quinazoline scaffolds.

• • Undergo nitro group reduction to produce functionalized aniline derivatives.
  • Serve as a building block for esterification and amidation reactions.
• Agrochemicals: Utilized as a building block for the synthesis of herbicides and pesticides.
• Wastewater Treatment: Investigated as an oxidation catalyst effective against pollutants like chlorantraniliprole. It also exhibits photocatalytic activity under visible light when combined with titanium dioxide.
• Dyes and Pigments: Used in the production of azo dyes and other coloring agents for the textile and manufacturing industries.
• Analytical Chemistry: Serves as a standard in chromatographic techniques to measure and analyze compounds in complex mixtures.
• Materials Science: Used to develop organic ligands and nonlinear optical (NLO) materials.

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