Uses
CAS 6091-44-7, known as Piperidine Hydrochloride, is primarily used as a crucial intermediate in synthesizing various pharmaceuticals (like anti-Parkinson’s drugs), a reagent in complex organic chemistry (Mannich reactions, asymmetric hydrogenation), and in advanced materials like perovskite solar cells, serving as a building block for new drugs and chemical compounds in research and industry.
Pharmaceutical Industry
- API Synthesis: Intermediate for drugs such as Biperiden (anti-Parkinson’s), Clocapramine (antidepressant), and Tolperisone (muscle relaxant).
- Drug Development: Used to create peripheral serotonin 5-HT3 receptor ligands and other pharmacologically active molecules.
Chemical Synthesis & Research
- Reagent: Used in important reactions like Mannich reactions, asymmetric hydrogenation, and chemoselective reductive amination.
- Building Block: For creating quinoline selenium compounds and phthalazinone derivatives with potential therapeutic uses.
- Analytical Standard: High-purity material used for method validation and quality control in labs.
Materials Science
- Perovskite Devices: Acts as a precursor in the preparation of advanced perovskite solar cells and other related devices.
Other Uses & Properties
- Solvent/Catalyst: Piperidine (the free base) has broader uses as a solvent and curing agent, with the hydrochloride salt serving related synthetic roles.
- Neuroprotective/Immunomodulatory: Research indicates it can block dopamine receptors and potentially offer neuroprotection and immune effects.
Applications
- Intermediate for APIs:Key building block for Active Pharmaceutical Ingredients (APIs).
- Anti-Parkinsonian Agents:Used to make Biperiden.
- Antidepressants:Involved in synthesizing Clocapramine hydrochloride.
- Muscle Relaxants:A precursor for Tolperisone.
- Neuroprotection:Shows potential in developing treatments for Parkinson’s disease and other neurological conditions, as it can block dopamine receptors and has immunomodulatory properties.
Chemical & Research Applications
- Organic Synthesis:Acts as a reactant or catalyst in various reactions, including Mannich reactions, asymmetric hydrogenation, and reductive amination.
- Ligand Synthesis:Used to create peripheral serotonin 5-HT3 receptor ligands.
- Phosphodiesterase Inhibitors:A reactant in synthesizing phthalazinone derivatives with potential as PDE4 inhibitors.
- Materials Science:A precursor for perovskite-based devices, especially in solar cell research.
Other Uses (Related to Piperidine)
- While the salt form (hydrochloride) is key, its parent compound, piperidine, is used as a solvent, rubber curing agent, and food additive, though safety precautions are vital
FAQs It should be stored in a cool, dry place in tightly sealed containers to maintain product stability and quality.
