Physical Properties of CBZ D-Proline CASNO: 6404-31-5
Appearance: White to off-white crystalline powder
Melting Point: 76–78 °C
Boiling Point: 432.3±45.0 °C (predicted at 760 mmHg)
Density: 1.3±0.1 g/cm³
Molecular Weight: 249.26 g/mol
Solubility: Slightly soluble in chloroform, DMSO, ethanol, and methanol.
Optical Rotation: + 40.2° c=2 in Ethanol
CBZ D-Proline CASNO: 6404-31-5
Storage Temperature: Store in a cool, dry, dark place, typically at room temperature.
Synonyms:
- N-Benzyloxycarbonyl-D-proline
- N-Carbobenzoxy-D-proline
- Z-D-Pro-OH
- Cbz-D-Pro-OH
- N-Cbz-D-proline
- (2R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
- 1-(Benzyloxycarbonyl)-D-proline
- (R)-1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester
- 1-benzyl hydrogen (R)-pyrrolidine-1,2-dicarboxylate
- PROLINA-Z-D
Uses:
Pharmaceutical Synthesis: It is used in the synthesis of peptide analogs, including trichostatin A and trapoxin B.
Enzyme Inhibition: It serves as a precursor for generating selective inhibitors for caspase-3 and caspase-7.
Chiral Building Block: Utilized in chemical research as a chiral starting material or intermediate for the synthesis of biologically active molecules and drugs.
Protein Engineering: Employed to introduce conformational constraints in proteins, assisting in the study of protein folding and stability.
Key Applications:
Peptide Synthesis & Drug Discovery: Serves as a key intermediate for creating specialized peptides and improving the stability/bioavailability of drug candidates.
Chiral Auxiliary/Ligand: Used in asymmetric synthesis to produce enantiomerically pure compounds, vital for fine chemical production.
Protein Engineering: Employed to introduce conformational constraints, assisting in the study of protein folding and stability.
Research & Development: Utilized in laboratories for studying proline metabolism and in general pharmaceutical R&D.
Anti-HIV/Antibacterial Agents: Derivatives of Cbz-D-Proline have been associated with antimicrobial and antiviral research.
