6404-31-5

CBZ D-Proline CASNO: 6404-31-5

Physical Properties: 

Appearance: White to off-white crystalline powder

Melting Point: 76–78 °C

Boiling Point: 432.3±45.0 °C (predicted at 760 mmHg)

Density: 1.3±0.1 g/cm³

Molecular Weight: 249.26 g/mol

Solubility: Slightly soluble in chloroform, DMSO, ethanol, and methanol.

Optical Rotation: + 40.2° c=2 in Ethanol

Storage Temperature: Store in a cool, dry, dark place, typically at room temperature.

Synonyms:

  • N-Benzyloxycarbonyl-D-proline
  • N-Carbobenzoxy-D-proline
  • Z-D-Pro-OH
  • Cbz-D-Pro-OH
  • N-Cbz-D-proline
  • (2R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
  • 1-(Benzyloxycarbonyl)-D-proline
  • (R)-1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester
  • 1-benzyl hydrogen (R)-pyrrolidine-1,2-dicarboxylate
  • PROLINA-Z-D
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 Uses:

Pharmaceutical Synthesis: It is used in the synthesis of peptide analogs, including trichostatin A and trapoxin B.

Enzyme Inhibition: It serves as a precursor for generating selective inhibitors for caspase-3 and caspase-7.

Chiral Building Block: Utilized in chemical research as a chiral starting material or intermediate for the synthesis of biologically active molecules and drugs.

Protein Engineering: Employed to introduce conformational constraints in proteins, assisting in the study of protein folding and stability.

Key Applications:

Peptide Synthesis & Drug Discovery: Serves as a key intermediate for creating specialized peptides and improving the stability/bioavailability of drug candidates.

Chiral Auxiliary/Ligand: Used in asymmetric synthesis to produce enantiomerically pure compounds, vital for fine chemical production.

Protein Engineering: Employed to introduce conformational constraints, assisting in the study of protein folding and stability.

Research & Development: Utilized in laboratories for studying proline metabolism and in general pharmaceutical R&D.

Anti-HIV/Antibacterial Agents: Derivatives of Cbz-D-Proline have been associated with antimicrobial and antiviral research.

What is CBZ–D-Proline (CAS 6404-31-5)?
CBZ–D-Proline is a protected amino acid derivative commonly used as an intermediate in organic synthesis and pharmaceutical research.
What are the uses of CBZ–D-Proline in chemical research?
It is widely used in peptide synthesis and as a building block in the development of pharmaceutical compounds and specialty chemicals.
What is the molecular formula and molecular weight of CBZ–D-Proline?
The molecular formula of CBZ–D-Proline is C13H15NO4, and its molecular weight is approximately 249.26 g/mol.
How should CBZ–D-Proline be stored and handled?
CBZ–D-Proline should be stored in a cool, dry place in a tightly sealed container, away from moisture and direct sunlight.
Where can I purchase high-purity CBZ–D-Proline CAS 6404-31-5?
CBZ–D-Proline is available from reliable chemical suppliers that provide high-purity materials suitable for research, pharmaceutical, and laboratory applications.

FAQs

What is CBZ–D-Proline (CAS 6404-31-5)?
CBZ–D-Proline is a protected amino acid derivative commonly used as an intermediate in organic synthesis and pharmaceutical research.
What are the uses of CBZ–D-Proline in chemical research?
It is widely used in peptide synthesis and as a building block in the development of pharmaceutical compounds and specialty chemicals.
What is the molecular formula and molecular weight of CBZ–D-Proline?
The molecular formula of CBZ–D-Proline is C13H15NO4, and its molecular weight is approximately 249.26 g/mol.
How should CBZ–D-Proline be stored and handled?
CBZ–D-Proline should be stored in a cool, dry place in a tightly sealed container, away from moisture and direct sunlight.
Where can I purchase high-purity CBZ–D-Proline CAS 6404-31-5?
CBZ–D-Proline is available from reliable chemical suppliers that provide high-purity materials suitable for research, pharmaceutical, and laboratory applications.

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