Physical Properties
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Molecular Formula: C₄H₇NO
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Molecular Weight: 85.11
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Appearance: Colorless liquid
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Density: 0.932 g/mL at 25°C
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Boiling Point: 82°C at 23 mmHg
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Melting Point: -19°C to -21°C
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Refractive Index: n20/D 1.399
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Solubility: Soluble in water, alcohols, and ether
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Vapor Pressure: 0.3 psi at 20°C
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Flash Point: 165°F (74°C)
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Stability: Decomposes upon heating or when exposed to water, acids, or alkali, releasing hydrogen cyanide (HCN).
Synonyms
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α-Hydroxyisobutyronitrile (Alpha-hydroxyisobutyronitrile)
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2-Methyllactonitrile
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Acetone cyanhydrin
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2-Cyano-2-propanol
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2-Hydroxyisobutyronitrile
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Acetoncyanhydrin
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Acetoncianidrina
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2-Hydroxy-2-methylpropionitrile
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Cyanohydrin-2-propanone
Uses
Acetone Cyanohydrin (CAS No: 75-86-5) is primarily used as a key intermediate in the production of methyl methacrylate (MMA), which is essential for manufacturing acrylic plastics and resins. It also acts as a source of hydrogen cyanide (HCN) in various chemical synthesis processes. Additionally, it is used as a raw material in the preparation of insecticides and in specialized organic reactions such as the Strecker reaction.
Key Applications
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Cyanation reactions of aryl halides, aldehydes, and alcohols
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Stereospecific epoxide ring opening reactions
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Strecker reaction of α-amido sulfones to synthesize α-amino nitriles
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Intermediate in the manufacturing of acrylic plastics and specialty chemicals
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Chemical synthesis processes in pharmaceutical and industrial chemistry





