Synonyms:
N-Benzoylglycine
Benzamidoacetic acid
Benzoylaminoacetic acid
Benzoyl glycocoll
Molecular Formula:
Molecular Weight: 179.18 g/mol
Uses: Used as an analytical reference standard in HPLC and GC-MS to test human urine.
Key Applications and Uses:
Benzoylglycine (Hippuric acid, used as a biomarker for metabolic studies (toluene exposure, diet) and in biochemical research. It acts as a key intermediate in chemical synthesis, particularly for amino acids, and as an analytical reagent in HPLC/GC-MS for quantifying metabolic compounds.
Biomarker for Exposure and Health:
Toluene Exposure: It is widely used as a biomarker to measure exposure to toluene.
Metabolic Studies: It is monitored as a indicator of dietary phenolic metabolism (e.g., wine, fruit juice consumption).
Clinical Diagnostics: It acts as a marker for potential neurological disorders, such as Parkinson’s disease.
Chemical Synthesis and Industrial Use:
Intermediate: Used in the synthesis of pharmaceuticals, peptides, and other organic compounds.
Erlenmeyer–Plöchl Synthesis: Utilized in the preparation of phenylalanine and other amino acids, often involving an oxazolone intermediate.
Analytical Standard: Used as a reference standard in HPLC and GC-MS for measuring urinary levels.
Other Applications:
Biochemical Research: Employed in studies related to enzyme substrate behavior, such as with hippurate hydroxylase.
